Structure and evolutionary history of a large family of NLR 1 proteins in the zebrafish 2 3 4
نویسندگان
چکیده
Structure and evolutionary history of a large family of NLR 1 proteins in the zebrafish 2 3 4 Kerstin Howe, Philipp H. Schiffer, Julia Zielinski, Thomas Wiehe, Gavin K. Laird, 5 John C. Marioni, Onuralp Soylemez, Fyodor Kondrashov, Maria Leptin 6 7 1 Wellcome Trust Sanger Institute, Cambridge, United Kingdom 8 2 Institut für Genetik, Universität zu Köln, Köln, Deutschland 9 3 The European Molecular Biology Laboratory, Heidelberg, Germany 10 4 The European Molecular Biology Laboratory, The European Bioinformatics Institute 11 (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, United Kingdom 12 5 Bioinformatics and Genomics Programme, Centre for Genomic Regulation (CRG) 88 Dr. 13 Aiguader, 08003 Barcelona, Spain. 14 6 Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain. 15 Institució Catalana de Recerca i Estudis Avançats (ICREA), 23 Pg. Lluís Companys, 08010 16 Barcelona, Spain. 17
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Structure and evolutionary history of a large family of NLR proteins in the zebrafish.
Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins. Mammals have small numbers of NLR proteins, whereas in some species, mostly those without adaptive immune systems, NLRs have expanded into very large families. We describe a family of nearly 40...
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